Pair Name | Lupeol, Fluorouracil | ||
Phytochemical Name | Lupeol (PubChem CID: 259846 ) | ||
Anticancer drug Name | Fluorouracil (PubChem CID: 3385 ) | ||
Structure of Phytochemical |
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2D
MOL
3D
MOL
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Structure of Anticancer Drug |
Download
2D
MOL
3D
MOL
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Pair Name | Lupeol, Fluorouracil | |||
Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
Biological Phenomena | Inhibition-->Cell metastasis | |||
Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
Down-regulation | Expression | BCL2 | hsa596 | |
Up-regulation | Expression | CDH1 | hsa999 | |
Down-regulation | Phosphorylation | EPHA2 | hsa1969 | |
Down-regulation | Phosphorylation | MET | hsa4233 | |
Down-regulation | Expression | MMP2 | hsa4313 | |
Down-regulation | Expression | SNAI1 | hsa6615 | |
Down-regulation | Expression | SNAI2 | hsa6591 | |
Down-regulation | Expression | TWIST1 | hsa7291 | |
Down-regulation | Expression | VIM | hsa7431 | |
In Vitro Model | MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 |
4T1 | Malignant neoplasms of the mouse mammary gland | Mus musculus (Mouse) | CVCL_0125 | |
In Vivo Model | 4T1 cells (1×10⁶) were injected into the abdominal mammary fat pads of BALB/c mice. | |||
Result | These data lay the foundation for the clinical validation of this combination therapy for TNBC patients. |
No. | Title | Href |
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1 | Lupeol synergizes with 5-fluorouracil to combat c-MET/EphA2 mediated chemoresistance in triple negative breast cancer. iScience. 2023 Nov 4;26(12):108395. doi: 10.1016/j.isci.2023.108395. | Click |